1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES
Omar, N., Ahmed, A., Ueda, H., El-Gizawy, S. (1989). 1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES. EKB Journal Management System, 12(2), 298-307. doi: 10.21608/bfsa.1989.72061
N. M. Omar; A. N. Ahmed; H. Ueda; S. M. El-Gizawy. "1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES". EKB Journal Management System, 12, 2, 1989, 298-307. doi: 10.21608/bfsa.1989.72061
Omar, N., Ahmed, A., Ueda, H., El-Gizawy, S. (1989). '1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES', EKB Journal Management System, 12(2), pp. 298-307. doi: 10.21608/bfsa.1989.72061
Omar, N., Ahmed, A., Ueda, H., El-Gizawy, S. 1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES. EKB Journal Management System, 1989; 12(2): 298-307. doi: 10.21608/bfsa.1989.72061

1H-NUCLEAR MAGNETIC RESONANCE (NMR) STUDY OF PIROXICAM-CYCLODEXTRINS INCLUSION COMPLEXES

Bulletin of Pharmaceutical Sciences Assiut University
Article 8, Volume 12, Issue 2, December 1989, Page 298-307  XML PDF (554.62 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1989.72061
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Authors
N. M. Omar1; A. N. Ahmed1; H. Ueda2; S. M. El-Gizawy1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Hoshi Institute of Pharmaceutical Sciences, Tokyo, Japan
Abstract
A structural study of the inclusion compounds of piroxicam with cyclodextrins (a-, b- and g-) in different molar ratios was studied by means of 1H-nuclear magnetic resonance (NMR) spectroscopy. The change in the chemical shift suggested that the drug pyridine moity was included in the cavity of cyclodextrins and most of the protons shifted to lower field with increasing the concentration of cyclodextrins. Plots of the molar ratio of cyclodextrins vs. the change in the chemical shift f piroxicam indicated that a 1:1 complex was formed.
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