INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS
Abdel Rahman, A., Aboutaleb, A., Mulley, B., Ahmed, S. (1989). INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS. EKB Journal Management System, 12(2), 308-324. doi: 10.21608/bfsa.1989.72062
Aly A. Abdel Rahman; A. E. Aboutaleb; B. A. Mulley; S. M. Ahmed. "INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS". EKB Journal Management System, 12, 2, 1989, 308-324. doi: 10.21608/bfsa.1989.72062
Abdel Rahman, A., Aboutaleb, A., Mulley, B., Ahmed, S. (1989). 'INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS', EKB Journal Management System, 12(2), pp. 308-324. doi: 10.21608/bfsa.1989.72062
Abdel Rahman, A., Aboutaleb, A., Mulley, B., Ahmed, S. INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS. EKB Journal Management System, 1989; 12(2): 308-324. doi: 10.21608/bfsa.1989.72062

INTERACTION OF TEMAZEPAM WITH CERTAIN MACROMOLECULES VIII- FORMULATION OF TABLETS CONTAINING TEMAZEPAM SOLID DISPERSIONS

Bulletin of Pharmaceutical Sciences Assiut University
Article 9, Volume 12, Issue 2, December 1989, Page 308-324  XML PDF (696.08 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1989.72062
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Authors
Aly A. Abdel Rahman1; A. E. Aboutaleb1; B. A. Mulley2; S. M. Ahmed1
1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2School of Pharmacy, Bradford University, England
Abstract
Temazepam-plyethylene glycol 6000 (PEG 6000) coprecipitates has been formulated as tablets using direct compression technique. This coprecipitation was chosen as it exhibited an optimum drug release characteristic and could be easily handled and pulverized.
Differential scanning calorimetery (DSC) was utilizes to check the compatibility of Temazepam with  Avicel pH 101and magnesium stearate as well as the effect of ageing on the formulated coprecipitates, at different storage conditions. It was concluded that the drug is compatible with those tablet excipients, and n detectable change resulted from ageing.
Compression of the formula containing 1:3 w/w Temazepam-PEG 6000 coprecipitates produced good quality tablets having rapid disintegration and rapid dissolution rates. Tablets of 1:7 w/w ratio were highly compact and having a lower disintegration and a lower dissolution rates. This shows the importance of optimizing the formulations by finding out the correct quantity of excipients to maintain better dissolution properties.
The results obtained indicated that 1:3 w/w Temazepam-PEG 6000 coprecipitates retains its higher dissolution when compressed as tablets. Additionally, this tablets formulation helped t provide Temazepam in a high quality dosage form.
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