Detection of 8-Hydroxy-2-Deoxyguanosine & Total Antioxidant Capacity in Saliva of Patients with Oral Premalignant & Malignant Lesions
Tarrad, N., Hassan, S., Shaker, O. (2019). Detection of 8-Hydroxy-2-Deoxyguanosine & Total Antioxidant Capacity in Saliva of Patients with Oral Premalignant & Malignant Lesions. EKB Journal Management System, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2283-2291. doi: 10.21608/edj.2019.72260
Nayroz Abdelfattah Tarrad; Sandy Shaaban Hassan; Olfat Gamel Shaker. "Detection of 8-Hydroxy-2-Deoxyguanosine & Total Antioxidant Capacity in Saliva of Patients with Oral Premalignant & Malignant Lesions". EKB Journal Management System, 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 2283-2291. doi: 10.21608/edj.2019.72260
Tarrad, N., Hassan, S., Shaker, O. (2019). 'Detection of 8-Hydroxy-2-Deoxyguanosine & Total Antioxidant Capacity in Saliva of Patients with Oral Premalignant & Malignant Lesions', EKB Journal Management System, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2283-2291. doi: 10.21608/edj.2019.72260
Tarrad, N., Hassan, S., Shaker, O. Detection of 8-Hydroxy-2-Deoxyguanosine & Total Antioxidant Capacity in Saliva of Patients with Oral Premalignant & Malignant Lesions. EKB Journal Management System, 2019; 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2283-2291. doi: 10.21608/edj.2019.72260

Detection of 8-Hydroxy-2-Deoxyguanosine & Total Antioxidant Capacity in Saliva of Patients with Oral Premalignant & Malignant Lesions

Egyptian Dental Journal
Article 5, Volume 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2019, Page 2283-2291  XML PDF (474.84 K)
Document Type: Original Article
DOI: 10.21608/edj.2019.72260
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Authors
Nayroz Abdelfattah Tarrad1; Sandy Shaaban Hassan1; Olfat Gamel Shaker2
1Lecturer of Oral Diagnosis, Oral Medicine and Periodontology, Department of Oral diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Fayoum University,
2Professor, Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt.
Abstract
Background: the current study investigated the level of salivary 8-hydroxy-2-deoxyguanosine & total antioxidant capacity in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant patients.
Methods: A total of 120 subjects diagnosed with leukoplakia (n=30), oral lichen planus (n=30), oral squamous cell carcinoma (n=30) & healthy control subjects (n=30) were included in this study. Salivary samples from all participants were collected. 8-hydroxy-2-deoxyguanosine was measured by enzyme linked immunosorbent assay technique and the level of total antioxidant capacity had been measured by means of photometric system.
Results: A significant higher salivary levels of 8-hydroxy-2-deoxyguanosine was observed in the group of oral squamous cell carcinoma in comparison to other groups. Comparing leukoplakia & oral lichen planus groups, no significant difference existed. Total antioxidant capacity showed its lowest value, with statistical significance, in oral squamous cell carcinoma patients. As between different grades of oral squamous cell carcinoma, significant difference had been registered in 8-hydroxy-2-deoxyguanosine between grade III and the other two grades while for total antioxidant only statistical significance existed between grade I and III.
Conclusion: Salivary 8-hydroxy-2-deoxyguanosine & total antioxidant capacity are noteworthy diagnostic markers that can be utilized in diagnosis of oral squamous cell carcinoma.
Keywords
Oral squamous cell carcinoma; saliva; 8-hydroxy-2-deoxyguinosine; Total Antioxidant Capacity
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