DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY
Hassan, S., Tarrad, N., Shaker, O. (2019). DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY. EKB Journal Management System, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2337-2345. doi: 10.21608/edj.2019.72269
Sandy Shaaban Hassan; Nayroz Abdel fattah Tarrad; Olfat Gamel Shaker. "DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY". EKB Journal Management System, 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 2337-2345. doi: 10.21608/edj.2019.72269
Hassan, S., Tarrad, N., Shaker, O. (2019). 'DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY', EKB Journal Management System, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2337-2345. doi: 10.21608/edj.2019.72269
Hassan, S., Tarrad, N., Shaker, O. DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY. EKB Journal Management System, 2019; 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2337-2345. doi: 10.21608/edj.2019.72269

DECREASED FERRITIN AND INCREASED HEPCIDIN SERUM LEVELS IN PERIODONTITIS PATIENTS WITH DIABETES MELLITUS TYPE 2: A CONTROLLED BEFORE-AND-AFTER STUDY

Egyptian Dental Journal
Article 11, Volume 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2019, Page 2337-2345  XML PDF (397.89 K)
Document Type: Original Article
DOI: 10.21608/edj.2019.72269
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Authors
Sandy Shaaban Hassan1; Nayroz Abdel fattah Tarrad1; Olfat Gamel Shaker2
1Lecturer, Department of Oral diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Fayoum University, Egypt
2Professor, Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt
Abstract
Objectives: The aim of the present work is to estimate the level of ferritin & hepcidin in serum of patients suffering from periodontitis and diabetes mellitus type 2 T2DM before and after non-surgical periodontal treatment.
Subjects and methods: Our study included 60 patients, categorized into 3 groups.
20 individuals with stage II grade B generalized periodontitis with T2DM (Group I), 20 others with stage II grade A generalized periodontitis (Group II) and 20 healthy volunteers (Group III). We obtained two serum samples from periodontitis patients before and after treatment in addition to one sample from each control subject. Serum ferritin & hepcidin levels were determined by using Enzyme linked immunosorbent assay technique (ELISA).
Results: The ferritin level was significantly higher in periodontitis groups than control in contrast to hepcidin that was eleveted in control group. A significant decrease in ferritin concentration but increase in hepcidin was noticed after 3 months. Receiver Operating Characteristic (ROC) curve analysis demonstrated more significant accuracy for ferritin than hepcidin on comparing both periodontitis groups with control.
Conclusions: As a prognostic marker for periodontitis, we could use ferritin but not hepcidin.
Keywords
Periodontitis; Type 2 diabetes mellitus; ferritin; hepcidin; non-surgical periodontal therapy
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