Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population
Abdel Moneim, W., Maged, A., Shaker, O. (2019). Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population. EKB Journal Management System, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2377-2386. doi: 10.21608/edj.2019.72275
Wesam Abdel Moneim; Amira Maged; Olfat G. Shaker. "Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population". EKB Journal Management System, 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 2377-2386. doi: 10.21608/edj.2019.72275
Abdel Moneim, W., Maged, A., Shaker, O. (2019). 'Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population', EKB Journal Management System, 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2377-2386. doi: 10.21608/edj.2019.72275
Abdel Moneim, W., Maged, A., Shaker, O. Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population. EKB Journal Management System, 2019; 65(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2377-2386. doi: 10.21608/edj.2019.72275

Effect of non-surgical periodontal therapy on serum and crevicular level of advanced glyacation end product in chronic periodontitis among a sample of the Egyptian population

Egyptian Dental Journal
Article 15, Volume 65, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2019, Page 2377-2386  XML PDF (785.03 K)
Document Type: Original Article
DOI: 10.21608/edj.2019.72275
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Authors
Wesam Abdel Moneim1; Amira Maged1; Olfat G. Shaker2
1Associate professor in Department of Oral Medicine and Periodontology, Faculty of dentistry, Cairo University.
2Professor in Department of Biochemistry, Faculty of Medicine, Cairo University.
Abstract
Background: AGEs are formed under oxidative conditions and are called advanced glyco-xidation end products. Periodontitis is a multifactorial inflammatory condition. The periodontal tissue damage is caused directly by bacteria and indirectly by inflammation and immunologic response against the bacteria. This inflammatory response is characterized by generation of prolonged release of neutrophil proteolytic enzymes, pro-inflammatory mediators and reactive oxygen species (ROS). Therefore, periodontitis is strictly linked to numerous pathologies which are related to production of oxidative stress and AGEs.
Methods: The study was conducted on thirty participants, they were divided into two groups; group (A) which included fifteen medically free subjects, and group (B) which included fifteen patients suffering from periodontitis. Serum and GCF samples were collected for assessment of AGEs before and after non -surgical periodontal therapy. Data were analysed by SPSS.
Results: Periodontitis group showed statistically significant higher mean AGE levels than control group in both serum and GCF samples. Moreover, there was a statistically significant decrease in AGE levels in both serum and GCF after treatment.
Conclusion: Crevicular level of AGEs can be used as a non-invasive diagnostic and prognostic biomarker for periodontitis.
Keywords
advanced glycation end products; Chronic Periodontitis; GCF
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