SYNTHESIS REACTIONS AND ANTIOXIDANT ACTIVITY OF SOME NEW HETEROCYCLES DERIVED FROM 2-ACETYLNAPHTHALENE | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 21, Volume 45, Issue 1 - Serial Number 45, March 2012, Page 338-351 PDF (421.82 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2012.7246 | ||||
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| Author | ||||
| Nadia Taha | ||||
| Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt ABSTRACT : | ||||
| Abstract | ||||
| 2-Methyl-4-(1-(naphthalen-2-yl)ethylidene)oxazol-5(4H)-one 2 was used as precursor for the preparation of some novel (1-(4-substituted)-2-methyl-4-(1-naphthalen-2-yl)ethylidene)-1H-imidazol-5(4H)-one derivatives 4a, b and other derivatives 3a,b, 5-12. Furthermore, the preparation of thieno[2,3-d]pyrimidin-4(3H)-one derivative 16,17 and 4-iminothieno[2,3-d] pyrimidin-3-ylamine derivative 18, 19 is described starting from 2-aminothiophen-3-carbonitrile derivative 15a. Some of the prepared products revealed a promising antioxidant activity by using 1,1-diphenyl-2,2-picryl hydrazyl free radical (DPPH) method. | ||||
| Keywords | ||||
| Imidazoles; thienopyrimidines; Antioxidant activity | ||||
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