ACYLATED (+)-CATECHIN GLYCOSIDES FROM ULMUS PUMILA L. GROWING IN EGYPT | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 27, Volume 45, Issue 1 - Serial Number 45, March 2012, Page 425-436 PDF (611.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2012.7252 | ||||
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| Author | ||||
| Said Esmail | ||||
| Department of Pharmacognosy, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Extensive isolation work on the n-BuOH-soluble fraction obtained from the stem and root barks of Ulmus pumila L. afforded five compounds. Four were identified as (+)-catechin 1, (+)-catechin 7-O-gallate 2, (+)-catechin-5-O-b-D-apiofuranoside 3, and (+)-catechin-7-O-b-D-apiofuranoside 4. The structures of the remaining new compound was elucidated to be, (+)-catechin-7-O-gallate-5-O-(5``-trans-caffeoyl)-b-D-apiofuranoside-3-O-b-D-apiofuranosyl-(1®2)-glucopyranoside 5, by chemical and spectroscopic analysis. The ethanolic and n-butanol extracts and the isolated compounds (1-5) were tested for their antioxidant activity using DPPH radical scavenging assay, xanthine oxidase-induced generation of superoxide radical and lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat tissue homogenates. | ||||
| Keywords | ||||
| Ulmus pumila L; Ulmuaceae; acylated (+)-catechin glycosides, DPPH , Xanthine oxidase, Lipid peroxidation | ||||
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