PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATION OF RUSSELIA EQUISTIFORMIS (SCROPHELARIACEAE) CULTIVATED IN EGYPT | ||||
| Al-Azhar Journal of Pharmaceutical Sciences | ||||
| Article 29, Volume 45, Issue 1 - Serial Number 45, March 2012, Page 455-474 PDF (886.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajps.2012.7254 | ||||
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| Author | ||||
| Atef El Hela | ||||
| Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University "Boys", Cairo. | ||||
| Abstract | ||||
| From the methanol extract of Russelia equisetiformis (Scrophelariaceae) cultivated in Egypt ten phenolic compounds were isolated and identified as gallic acid, methylgallate, vicenin II, chrysoeriol-7-O-ß-D-4C1 glucopyranoside, luteolin 7-O-glucoside, luteolin-7-O-ß-D-4C1-arabinoside, quercetrin, apigenin, luteolin and acetoside. The structures of the isolated compounds were elucidated on the basis chromatographic and spectroscopic data (UV, IR and NMR) where all compounds were isolated for the first time except acetoside. The biological investigation antidepressant and hepatoprotective effect of different extracts of Russelia equisetiformis was carried out, concerning the antidepressant property the n-butanol was the most active, followed by aqueous and crude phenylethanoids extract respectively and Fluoxetine as reference standard, while the hydro-alcohol extract exhibited significant hepatoprotective effect against carbon tetrachloride injured liver cells | ||||
| Keywords | ||||
| Russelia equisetiformis; Phenolic compounds; Antidepressant; fluoxetine; Hepatoprotective; Carbon tetrachloride | ||||
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