Immunoexpression of Ki-67 and Cyclooxygenase-2 in Odontogenic Keratocyst and Dentigerous Cyst: A Comparative Study | ||||
| Egyptian Dental Journal | ||||
| Article 22, Volume 65, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2019, Page 1367-1375 PDF (1.27 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2019.72561 | ||||
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| Author | ||||
| Enas Alaa Eldin Abd El-Aziz | ||||
| Lecturer of Oral and Maxillofacial Pathology, Faculty of Dentistry, Minia University. | ||||
| Abstract | ||||
| Aims: To evaluate the expression of Cyclooxygenase-2 (COX-2) in odontogenic keratocyst (OKC) and dentigerous cyst and correlate it with Ki-67 expression in these lesions. Material and Methods: This study was carried out on 32 paraffin embedded specimens of dentigerous cyst and OKC. 16 samples obtained from healthy mucosa served as controls. Slides prepared from paraffin-embedded sections were immunohistochemically stained for Ki-67 and COX-2 and immunoreactivity of the two markers was evaluated using index of positivity and staining intensity. Statistical analysis was performed using Mann-Whitney and Spearman’s correlation tests. Results: Ki-67 and COX-2 expression in OKC and dentigerous cyst was found to be significantly higher than those observed in healthy mucosa groups (p < 0.05). The expression of the two markers was significantly higher in OKC than in dentigerous cyst. A positive correlation was found between the two markers in both lesions. Conclusions: Increased expression of Ki-67 and COX- 2 in OKC is an indicator of the high mitotic activity of these lesions compared with dentigerous cyst. COX-2 is implicated in odontogenic epithelial proliferation in OKC and dentigerous cyst. | ||||
| Keywords | ||||
| Ki-67; COX-2; OKC; dentigerous cyst | ||||
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