The Antiproliferative Activity and Molecular Docking Studies of Some Sulfonamides against Cancer Cell Lines Compared to Normal Cells | ||||
Egyptian Journal of Chemistry | ||||
Article 4, Volume 61, Issue 3, May and June 2018, Page 423-429 PDF (568.9 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2018.2934.1242 | ||||
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Authors | ||||
Abdel-Mohsen M. Soliman 1; Mohsen Kamel1; Ahmed F. Eweas1; Joanna Wietrzyk2; Magdalena Milczarek2 | ||||
1Department of Therapeutic Chemistry National Research Centre, El-Buhouth St., P.O. 12622, Dokki, Giza, Egypt | ||||
2Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland | ||||
Abstract | ||||
Some new and known substituted 1,2,3,4-tetrahydroacridines incorporated at their position nine with various sulfa drug or thiosemicarbazide moieties were synthesized. Biologically, these compounds were investigated for their antiproliferative activity against human breast cancer (MCF-7) cell line compared to murine fibroblast normal cell line (BALB/3T3). The results were calculated as the IC50 (inhibitory concentration 50%) compared with Cisplatin as control. Furthermore, a docking simulation study was carried out to predict the inhibitory mode of action of the most active compounds. | ||||
Keywords | ||||
Antiproliferative activity; sulphonamides; MCF-7; BALB/3T3; Molecular docking | ||||
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