FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN
Sakr, F., Abd El-Gawad, A., Zin El-Din, E. (1988). FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN. EKB Journal Management System, 11(1), 1-17. doi: 10.21608/bfsa.1988.73265
F. M. Sakr; A. H. Abd El-Gawad; E. E. Zin El-Din. "FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN". EKB Journal Management System, 11, 1, 1988, 1-17. doi: 10.21608/bfsa.1988.73265
Sakr, F., Abd El-Gawad, A., Zin El-Din, E. (1988). 'FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN', EKB Journal Management System, 11(1), pp. 1-17. doi: 10.21608/bfsa.1988.73265
Sakr, F., Abd El-Gawad, A., Zin El-Din, E. FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN. EKB Journal Management System, 1988; 11(1): 1-17. doi: 10.21608/bfsa.1988.73265

FORMULATION AND EVALUATION OF BEADS AND MOLDED PREPARATIONS CONTAINING GRISEOFULVIN

Bulletin of Pharmaceutical Sciences Assiut University
Article 1, Volume 11, Issue 1, June 1988, Page 1-17  XML PDF (632.67 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1988.73265
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Authors
F. M. Sakr; A. H. Abd El-Gawad; E. E. Zin El-Din
Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Abstract
Solid dispersion containing polyethylene glycols (PEG) and different ratios of griseofulvin were made into beads and molded tablets. Beads were prepared by a newly designed technique referred to as the "dry solidification technique" (DST). This was based on dropping the molten drug-polymer mixtures from a syringe needle onto top of talc powder beds chosen as solidification substances. Molded tablets were obtained by pouring the molten mixture into a tablet triturate mold placed on aluminium foil sheets. The formed beads and tablets were examined for their physicomechanical properties and physiological availabilities. Increasing drug contents and PEG mol. Wts. were found to increase beads and tablets hardness while decreased their dissolution rates and resistance to abrasions. The mechanical properties and dissolution rates of the molded tablets were also compared with those of hardly compressed tablets containing ranges of particle size between 125-150 mm (A) and 212-250 mm (B) of corresponding solid dispersions. Molded tablets were found to be mechanically stronger than those of (A) and (B) respectively, however their dissolution rates remained almost the same. Bioavailability results of the different preparations were found to be parallel with those of their dissolution rates; so that maximum urinary excretion of the drug and higher physiological availability were observed in case of beads rather than those of molded or compressed tablets. 
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