Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes
El-Mesallamy, A., Hussein, S., Hussein, A., Mahmoud, S., El-Azab, K. (2018). Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes. EKB Journal Management System, 61(4), 609-615. doi: 10.21608/ejchem.2018.3550.1297
Amani MD El-Mesallamy; Sahar Hussein; Abdel Aziz M Hussein; Seham A Mahmoud; Khalid M. El-Azab. "Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes". EKB Journal Management System, 61, 4, 2018, 609-615. doi: 10.21608/ejchem.2018.3550.1297
El-Mesallamy, A., Hussein, S., Hussein, A., Mahmoud, S., El-Azab, K. (2018). 'Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes', EKB Journal Management System, 61(4), pp. 609-615. doi: 10.21608/ejchem.2018.3550.1297
El-Mesallamy, A., Hussein, S., Hussein, A., Mahmoud, S., El-Azab, K. Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes. EKB Journal Management System, 2018; 61(4): 609-615. doi: 10.21608/ejchem.2018.3550.1297

Reno-protective Effect of Methanolic Extract of Stevia Rebaudiana Bertoni and Bioactive Phenolic Compounds In Type-1- Diabetes

Egyptian Journal of Chemistry
Article 4, Volume 61, Issue 4, July and August 2018, Page 609-615  XML PDF (1.14 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.3550.1297
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Authors
Amani MD El-Mesallamy1; Sahar Hussein email orcid 2; Abdel Aziz M Hussein3; Seham A Mahmoud1; Khalid M. El-Azab4
1Department of Organic Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
2Department of Phytochemistry and Plant Systematics ,National Research Center , Egypt
3Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
4Department of Biology, Faculty of Science, JazanUniversity, Jazan, Saudi Arabia
Abstract
The aim of this study is to evaluate the reno-protective effect of the defatted methanolic extract of Stevia rebaudiana which showed the highest improvement of renal parameters, as it reduced the protein urea, blood urea nitrogen and blood creatinine and nephroprotective properties with reduced hyperglycemia complications through protection of renal tissues in type-1 diabetes. Also, identification of bioactive phenolic compounds of defatted methanolic extract using HPLC analysis, demonstrate the presence of diterpene glycosides, stevioside, rebaudioside A and chlorogenic acid
Keywords
Stevia rebaudiana; diterpene glycosides; chlorogenic acid; Phenolic; Flavonoids; HPLC; diabetic nephropathy
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