SPECTROPHOTOMETRIC ASSAY OF CERTAIN BENZODIAZEPINE DRUGS THROUGH COMPLEX FORMATION REACTION | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 11, Issue 1, June 1988, Page 141-153 PDF (429.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1988.73485 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Michael E. El-Kommos; Kamla M. Emara | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt | ||||
| Abstract | ||||
| A simple and accurate spectrophotometric method was developed for the determination of diazepam, prazepam and flunitrazepam. The method is based on the interaction of the benzodiazepine drug containing an active methylene group with 1,3-dinitrobenzene in presence of tetraethylammonium hydroxide to form a violet coloured d-complex (lmax=560 nm). Beer's law is obeyed over the concentration ranges 2-20 mg ml-1 (for diazepam), 5-30 mg ml-1 (for prazepam) and 5-40 mg ml-1 (for flunitrazepam). The method was successfully applied to the assay of the cited drugs in pure form and in pharmaceutical formulations. Results obtained agree well with those of official methods. | ||||
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