Role of Serum Amyloid A Protein in the Early Detection of Late Onset Sepsis in Neonate
Abd Elkhalek, H., Abed, N., Abdel Haie, O., Goda, S. (2020). Role of Serum Amyloid A Protein in the Early Detection of Late Onset Sepsis in Neonate. EKB Journal Management System, 37(1), 155-168. doi: 10.21608/bmfj.2020.73932
Heba Mohammed Abd Elkhalek; Neeven Abed; Omima Abdel Haie; Seham Goda. "Role of Serum Amyloid A Protein in the Early Detection of Late Onset Sepsis in Neonate". EKB Journal Management System, 37, 1, 2020, 155-168. doi: 10.21608/bmfj.2020.73932
Abd Elkhalek, H., Abed, N., Abdel Haie, O., Goda, S. (2020). 'Role of Serum Amyloid A Protein in the Early Detection of Late Onset Sepsis in Neonate', EKB Journal Management System, 37(1), pp. 155-168. doi: 10.21608/bmfj.2020.73932
Abd Elkhalek, H., Abed, N., Abdel Haie, O., Goda, S. Role of Serum Amyloid A Protein in the Early Detection of Late Onset Sepsis in Neonate. EKB Journal Management System, 2020; 37(1): 155-168. doi: 10.21608/bmfj.2020.73932

Role of Serum Amyloid A Protein in the Early Detection of Late Onset Sepsis in Neonate

Benha Medical Journal
Article 2, Volume 37, Issue 1, May 2020, Page 155-168  XML PDF (964.98 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.73932
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Authors
Heba Mohammed Abd Elkhalek email 1; Neeven Abed2; Omima Abdel Haie2; Seham Goda3
1pediatric, benha faculty of medicine
2Department of pediatric, Benha faculty of medicine, Benha University, Egypt
3Department of Clinical and Chemical Pathology Faculty of Medicine, Benha University, Egypt
Abstract
Background: Late onset sepsis (LOS) is an important cause of serious illness and deaths among neonates.  Diagnosis of neonatal sepsis remains a challenge owing to nonspecific early clinical signs and the non-availability of a reliable biomarker. Serum amyloid A (SAA), the precursor protein in inflammation-associated reactive amyloidosis, whose level in the blood increases up to 1000 fold in response to inflammation and it is also an acute phase reactant like PCT and CRP. Objectives: assessing the accuracy and rapidity of SAA in detection of LOS in neonates. Method: This is a case-control study which was carried out on neonates admitted in (NICU) of Benha University Hospital and Benha Teaching Hospital during the period (from June 2018 to November 2019). Group 1 (patients group): 45 neonates with neonatal sepsis, group 2 (control group): 40 healthy neonates age and sex matched. SAA was measured. Results: mean value of SAA in septic group was 38.8 µg/ml compared to 1.26 µg/ml in control group , with statistically significant increase in patients than controls (p<0.001). ROC curve was done to show the performance of SAA in the prediction of LOS. It was found that at a cut-off value of SAA >2.8 µg/ml, SAA had a sensitivity 86.7%, specificity 85%, PPV 86.7%, and NPV 85% for early diagnosis of LOS. At a cut-off value of SAA>45.2 µg/ml, SAA had a sensitivity 83.3%, specificity 69.7%, PPV 50%, and NPV 92% for the prediction of mortality among LOS patients. Conclusion: The high sensitivity, specificity, positive predictive value and negative predictive value of SAA protein could help the clinicians for early diagnosis of LOS.
Keywords
Serum Amyloid A; Late Onset neonatal Sepsis; Diagnosis
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