PHARMACOLOGICAL EVALUATION OF SOME OXAMIDE DERIVATIVES ON CEREBRAL ACTIVITY | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 5, Volume 10, Issue 1, June 1987, Page 84-94 PDF (402.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1987.74045 | ||||
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| Authors | ||||
| H. I. El-Bitar; R. A. Abdel Aal | ||||
| Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The present study was adopted in an attempt to evaluate the anticonvulsant and central epressant activity of five N-substituted-N-(2-methyl-4-oxoquinazolin-3-yl) oxamides. The anticonculsant activity was determined against both electroshock and pentyleneterazole induced seizures in mice. The CNS deperessant activity was indicated by measuring their effect on the spontaneous motor activity of mice using the activity cage apparatus. Diazepam was used in the experiments as a reference drug for comparative purpose. Results of the present study revealed that most of the compounds in question possess variable degree of anticonvulsant and CNS depressant activity and the compound N-Isopropyl-N-(2-methyl-4-0x0quinazolin-3-yl) oxamide displayed the greatest response. Intraperitoneal injection of this compound into rabbits has not led to any remarkable change in the ECG, blood pressure or respiration. However on weight basis the magnitude f diazepam response is greater than any of the tested compounds. | ||||
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