ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS
Ismail, S., Habib, F., El-Shanawany, S., Fouad, E. (1987). ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS. EKB Journal Management System, 10(1), 95-111. doi: 10.21608/bfsa.1987.74047
S. Ismail; F. S. Habib; S. El-Shanawany; E. A. Fouad. "ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS". EKB Journal Management System, 10, 1, 1987, 95-111. doi: 10.21608/bfsa.1987.74047
Ismail, S., Habib, F., El-Shanawany, S., Fouad, E. (1987). 'ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS', EKB Journal Management System, 10(1), pp. 95-111. doi: 10.21608/bfsa.1987.74047
Ismail, S., Habib, F., El-Shanawany, S., Fouad, E. ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS. EKB Journal Management System, 1987; 10(1): 95-111. doi: 10.21608/bfsa.1987.74047

ON THE INTERACTION BETWEEN RIFAMPICIN AND MACROMOLECULES II. MYRJS AND BRIJS

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 10, Issue 1, June 1987, Page 95-111  XML PDF (427.52 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1987.74047
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Authors
S. Ismail; F. S. Habib; S. El-Shanawany; E. A. Fouad
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
The permeation rate constant of rifampicin in presence of Hyrj 52, Myrj 53, Myrj 59, Brij 35 and Brij 58 was studied utilizing the dynamic dialysis technique. The presence of Myris or Brij in rifampicin solution markedly decreased the permeation rate constant. Generally, the apparent transfer rate constant is inversely proportional to the surfactant concentration. The most reducing effect was exhibited in case of Brij 35. This may be due to a high affinity of the drug to interact with this surfactant than the other tested ones.
The Langmuir plots for the interaction between rifampicin and surfactant showed g-intercept indicating that the complex formation is a factor in the binding of rifampicin by surfactants. Furthermore, the presence of surfactant in rifampicin solution was found to reduce its antibacterial activity against S. aureus.
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