Influence of Nanocomposite Scaffolds Using Freeze-drying Technique on Hepg2
El gohary, M., Kamal, G., El-Meliegy, E., Awad, S., El-tohamy, A. (2017). Influence of Nanocomposite Scaffolds Using Freeze-drying Technique on Hepg2. EKB Journal Management System, 18(1), 36-45. doi: 10.21608/ejbbe.2018.2743.1013
Mohamed Ismail El gohary; Gehan Mohamed Kamal; Emad El-Meliegy; Sahar Awad; Asmaa El-tohamy. "Influence of Nanocomposite Scaffolds Using Freeze-drying Technique on Hepg2". EKB Journal Management System, 18, 1, 2017, 36-45. doi: 10.21608/ejbbe.2018.2743.1013
El gohary, M., Kamal, G., El-Meliegy, E., Awad, S., El-tohamy, A. (2017). 'Influence of Nanocomposite Scaffolds Using Freeze-drying Technique on Hepg2', EKB Journal Management System, 18(1), pp. 36-45. doi: 10.21608/ejbbe.2018.2743.1013
El gohary, M., Kamal, G., El-Meliegy, E., Awad, S., El-tohamy, A. Influence of Nanocomposite Scaffolds Using Freeze-drying Technique on Hepg2. EKB Journal Management System, 2017; 18(1): 36-45. doi: 10.21608/ejbbe.2018.2743.1013

Influence of Nanocomposite Scaffolds Using Freeze-drying Technique on Hepg2

Egyptian Journal of Biomedical Engineering and Biophysics
Article 4, Volume 18, Issue 1, 2017, Page 36-45  XML PDF (1.3 MB)
Document Type: Original Article
DOI: 10.21608/ejbbe.2018.2743.1013
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Authors
Mohamed Ismail El goharyorcid 1; Gehan Mohamed Kamal2; Emad El-Meliegy3; Sahar Awad4; Asmaa El-tohamy email 5
1Physics Dpt., faculty of science (boys), Al azhar University
2Physics Dpt., faculty of science (girls), Al azhar University
3Ceramics and Building materials Dept., National Research Centre, 12622 El-Tahrir street, Dokki, Cairo
4Biophysics branch, Physics Department, Faculty of Science, Al-Azhar University(girls), Nasr City 11884, Cairo, Egypt.
5biophysics, Azhar university
Abstract
Novel approaches are devoted towards creating 3D scaffolds that allow good permeability and diffusion. Appropriate synthetic biodegradable materials for this purpose are biopolymer- bioceramic nanocomposites. They have good tissue compatibility and safety profiles seem essential for their successful utilization in medical applications. The 3D dicalcium phosphate/dextran/ sodium carboxymethyl cellulose nanocomposites are prepared by freeze-drying method. In the present work, the physico-chemical properties of scaffolds are evaluated by XRD and FTIR. The interior morphology as well as porous structure are evaluated by scanning electron microscope (SEM). The porosity of scaffolds examined by mercury intrusion porosimetry (MIP). In addition to compressive stress parameter is also determined by Instron Industrial Product,(Model 3345;Norwood, MA, USA).The respective nanocomposite scaffolds are tested for in vitro Hepg2 cancer cytotoxicity. The nanocomposite scaffolds exhibit good biocompatibility and exerts no toxic effect on Hepg2 liver cancer cell. Therefore, the prepared porous system of nanocomposite scaffolds can be considered as promising technique for tissue engineering.
Keywords
Dicalcium phosphate; Dextran; Nanocomposite; 3D Scaffold
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