GORLIN GOLTZ SYNDROME: A CASE REPORT | ||||
| Egyptian Dental Journal | ||||
| Article 12, Volume 63, Issue 2 - April (Oral Surgery), February 2017, Page 1295-1302 PDF (1.54 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2017.74355 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nermine Ramadan 1; Yasser F. Habaka2
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| 1Lecturer Oral And Maxillofacial Surgery, Oral Surgery Department, October 6 University | ||||
| 2Assistant Lecturer Oral And Maxillofacial Surgery, Oral Surgery Department, October 6 University | ||||
| Abstract | ||||
| Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, being due to a genetic alteration which produced by mutation in the “Patched” tumor suppressor gene, and it is inherited in an autosomal dominant way. This syndrome is about multisystemic process that is characterized by the presence of multiple pigmented basocellular carcinomas, odontogenic keratocysts in the jaws, palmar and/or plantar pits and calcification of falx cerebri. Together with these major features a great number of processes considered as minor features have also been described which include numerous skeletal, dermatological and neurological anomalies among others. Due to the importance of oral and maxillofacial manifestations of this syndrome, it is fundamental to know its characteristic in order to make a diagnosis, an early preventive treatment and establish right genetic advice. | ||||
| Keywords | ||||
| Gorlin-Goltz; basocellular carcinoma; odontogenic keratocysts | ||||
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