SPECTROPHOTOMETRIC DETERMINATION OF SOME HALOGENATED 8-HYDROXYQUINOLINES WITH ZIRCONYL CHLORIDE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 10, Issue 2, December 1987, Page 71-84 PDF (422.71 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1987.74397 | ||||
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| Authors | ||||
| I. H. Refaat; M. E. El-Kommos; H. H. Farag; N. A. El-Rabat | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A spectrophotometric method is described for the determination of 8-hydroxyquinoline (oxine) and three of its halogenated derivatives: 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol), 5,7-diiodo-8- hydroxyquinoline (iodoquinol) and 7-iodo-8- hydroxyl-5-quinoline sulphonic acid (chiniofon). The method involves the use of zirconyl chloride in methanolic medium to give highly absorbing chelates with lmax at 364 nm (oxine), 367 nm (chiniofon), or 389 nm (clioquinol and iodoquinol). The molar ratio of the reaction was established and the characteristic features of the IR spectra of the chelates were discussed. The procedure described was applied successfully to the determination of the named compounds in dosage forms and the results obtained were comparable with official methods. | ||||
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