DISSOLUTION BEHAVIOUR OF METRONIDAZOLE TABLETS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 10, Issue 2, December 1987, Page 123-138 PDF (497.32 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1987.74400 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| E. A. Ibrahim; S. S. Tous; T. H. El-Faham; M. A. Hassan | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The dissolution behavior of metronidazol tablets from three locally manufactured brands on the Egyptian market was studied. Four batches from each brand were collected from the market. The compliance of the tablets collected to the USP XX requirements was evaluated. Some batches from certain brands sis not pass the USP XX requirements for disintegration time, potency and weight variation. The USP XX paddle method was used for the dissolution studies. 0.1 N HCl at 37°C was used as the dissolution medium. Nine tablets from each batch were considered in the dissolution study. The results revealed significant differences among and within the batches of the same brand for the percent metronisazole dissolved after 10, 30 and 105 minutes at p£ 0.1 significance level. Moreover a significant difference was found to exist between different brands. The dissolution rate of drug powder was found to be higher than that of tablets. Furthermore, the drug powder filled into capsules showed higher dissolution behaviour than tablets and lesser than drug powder. In addition, the bioavailability of the drug powder filled into capsules as well as tablets, was studied. The results revealed that there was a correlation between the in-vitro dissolution rate of the drug and its in-vivo absorption data. | ||||
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