EFFECT OF COPRECIPITATE FORMATION AND CERTAIN NON-IONIC SURFACTANTS ON CHLORDIAZEPOXIDE RELEASE FROM CAPSULES | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 4, Volume 9, Issue 1, June 1986, Page 40-59 PDF (595.87 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1986.74474 | ||||
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| Authors | ||||
| A. E. Aboutaleb; Aly A. Abdel Rahman; E. M. Samy | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The solvent method was employed to prepare coprecipitates with certain carriers and the water-insoluble drug chlordiazepoxide to enhance its dissolution rate. The investigated carrierswere: poly-ethylene glycol 4000 (PEG 4000), polyvinylpyrrolidone 44000 (PVP 44000) and a-cyclodextrin (a-CYC) in ratios 1:1, 1:3 and 1:7 (drug: carrier), respectively. The dissolution rate of chlordiazepoxide from its prepared coprecipitates using the previously mentioned carriers, especially a-CYC, was found to be higher than that of the drug alone in 0.1N HCl as a dissolution medium. The effect of certain non-ionic surfactant solutions including Brih 35 and Eumulgin C1000 on the release of chlordiazepoxide from the prepared coprecipitates was also investigated. It was found that the investigated surfactants in the concentration used (0.1% W/V), produced better drug release than the control, especially when PEG 4000 was used as a carrier. The mode of interaction taking place between chlordiazepoxide and the investigated carriers was studied by different techniques including UV, IR, chromatography and differential thermal analysis, where a complex formation between chlordiazepoxide and coprecipitating agents was revealed. | ||||
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