FORMULATION OF AZAPROPAZONE SUPPOSITORIES AND EXAMINATION OF ITS EFFECT ON THE GASTROINTESTINAL TRACT OF RABBITS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 9, Issue 1, June 1986, Page 71-88 PDF (683.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1986.74476 | ||||
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| Authors | ||||
| A. T. I. Nouh; E. M. Ramadan; A. H. Abdel-Gawad | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| The rectal absorption of azapropazone, in rabbits, from different suppository formulations was investigated, and compared with its in-vitro release. A comparison between the rectal absorption of the drug and its absorption from capsule was done. The effect of azapropazone on the gastrointestinal tract of rabbits was studied. It was proved that the rectal absorption of the drug is a function of the nature or suppository bases. Of the tested bases, a base consisting of a mixture of PEG 6000, 1540 and 400 (47:33:20) gave the highest in-vitro release, however Witepsol Hl5 produced the highest rectal absorption of the medicament. The availability of azapropazone from the capsules was much better than that from the suppositories. The effect of the orally and rectally administered drug on the duodenal mucosa was deleterious with a marked ulceration. No ulcerative changes could be detected on the rectal mucosa in any of the tested groups of rabbits. On the gastric mucosa, there was a pronounced ulcerative changes in case of oral administration | ||||
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