COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 10, Volume 9, Issue 1, June 1986, Page 137-148 PDF (329.52 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1986.74480 | ||||
View on SCiNiTO | ||||
Authors | ||||
S. R. El-Shabouri; A. F. Youssef; F. A. Mohamed; A-M. I. Rageh | ||||
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt | ||||
Abstract | ||||
The color intensity developed from the reaction of twelve phenothiazine drugs with I3 has been correlated using physicochemical substituent like Hammett constant sp, and molecular connectivity 1Xv. Results indicated a predominant role of electronic parameter in determining color intensity. The bulkiness described by 1Xv played a significant role. However, other parameters of the side chain were also prominent. Working up multiple parametric regression can be used as a reliable tool to predict the sensitivity and scope of the colorimetric method for other phenothiazines. | ||||
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