EVALUATION OF THE SALIVARY LEVEL OF MIR-21 IN CIGARETTE SMOKERS: CASE-CONTROL STUDY | ||||
| Egyptian Dental Journal | ||||
| Article 10, Volume 63, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2017, Page 1507-1512 PDF (447.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2017.74547 | ||||
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| Authors | ||||
| Shereen Ali1; Eman Amer2 | ||||
| 1Lecturer, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University | ||||
| 2Associate Professor, Department of Medical Biochemistry, Faculty of Pharmacy, Ahram Canadian University. | ||||
| Abstract | ||||
| Background: Salivary biomarkers are attractive non-invasive tools for screening oral cancer especially in high risk individuals such as smokers. The present study observed the salivary level of microRNA-21 to verify their value as diagnostic marker for smokers. Methods: The study sample comprised 40 males: 20 non-smokers and 20 smokers. Whole unstimulated saliva samples were collected. The resulting data was analyzed for any statistical significance. Results: Smokers had statistically significant higher salivary microRNA-21 level than non-smokers. Conclusions: Our study demonstrated elevated levels of salivary microRNA-21 in cigarette smokers. Salivary miR-21 could be a promising new diagnostic marker for cigarette smokers. We recommend conducting further studies to investigate its diagnostic value as a marker for oral cancer susceptibility in cigarette smokers. | ||||
| Keywords | ||||
| MicroRNA-21; Smokers; Diagnostic marker; Salivary biomarkers | ||||
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