IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS
Bodor, N., El-Kommos, M., Nath, C. (1986). IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS. EKB Journal Management System, 9(2), 14-29. doi: 10.21608/bfsa.1986.74571
N. Bodor; M. E. El-Kommos; Ch. Nath. "IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS". EKB Journal Management System, 9, 2, 1986, 14-29. doi: 10.21608/bfsa.1986.74571
Bodor, N., El-Kommos, M., Nath, C. (1986). 'IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS', EKB Journal Management System, 9(2), pp. 14-29. doi: 10.21608/bfsa.1986.74571
Bodor, N., El-Kommos, M., Nath, C. IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS. EKB Journal Management System, 1986; 9(2): 14-29. doi: 10.21608/bfsa.1986.74571

IN-VIVO ELIMINATION OF DIHYDROPYRIDINE DRUG DELIVERY CARRIERS FROM BRAIN AND BLOOD OF RATS

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 9, Issue 2, December 1986, Page 14-29  XML PDF (432.48 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1986.74571
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Authors
N. Bodor1; M. E. El-Kommos2; Ch. Nath1
1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, U.S.A
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
The dihydropyridine « pyridinium salt redox delivery system, used for specific delivery and sustained release of drugs in the brain was studied. The rates of elimination of the ester and acid metabolites of l-methyl- 3-(ethoxycarbonyl)-1,4-dihydrpyridine and of 1-(2-ethoxycarbonyl) ethyl-1,4-dihydronicotinamide from brain and blood of rats after systemic administration of dihydro carrier-ethanol couples were investigated, taking ethanol as a model drug. It was found that the quaternary species are eliminated relatively fast, which supports the hypothesis for existence of an active transport mechanism for eliminating organic ions from the brain. The results can serve as a primary evidence for the suggestion that the carrier and its metabolites will not impair central nervous system functions.
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