BIOAVAILABILITY AND EROSIVE ACTIVITY OF SOME NON-STEROIDAL ANTI-INFLAMMATORY DRUGS SOLID-DISPERSIONS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 3, Volume 9, Issue 2, December 1986, Page 30-49 PDF (945.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1986.74572 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| E. Ramadan; A. G. H. Abd El-Gawad; A. T. Nouh | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Solid dispersions of mefenamic acid, azapropazone, glafenine and floctafenine were prepared with PVP K25 and PEG 6000 in a ratio of 1:1 w/w. Bioavailability and erosive activity of these drugs were investigated using their solid dispersions. The obtained results revealed that the coprecipitate of such drugs with PVP enhances their bioavailability and significantly inhibits the ulcerogenic effect of the drugs under investigation. However, solid dispersions with PEG enhance bioavailability but slightly reduce their gastric ulceration. | ||||
|
Statistics Article View: 80 PDF Download: 135 |
||||
