SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES
Bayoumi, B., Abd-Alla, M., Ahmed, A. (1986). SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES. EKB Journal Management System, 9(2), 66-77. doi: 10.21608/bfsa.1986.74575
B. E. Bayoumi; M. A. Abd-Alla; A. N. Ahmed. "SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES". EKB Journal Management System, 9, 2, 1986, 66-77. doi: 10.21608/bfsa.1986.74575
Bayoumi, B., Abd-Alla, M., Ahmed, A. (1986). 'SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES', EKB Journal Management System, 9(2), pp. 66-77. doi: 10.21608/bfsa.1986.74575
Bayoumi, B., Abd-Alla, M., Ahmed, A. SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES. EKB Journal Management System, 1986; 9(2): 66-77. doi: 10.21608/bfsa.1986.74575

SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 5, Volume 9, Issue 2, December 1986, Page 66-77  XML PDF (339.1 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1986.74575
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Authors
B. E. Bayoumi1; M. A. Abd-Alla2; A. N. Ahmed3
1Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
2Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Several 4-{4-(substitutedglycylamino)-phenyl}-1,2,3-selenadiazols (IV) and 4{4-(substitutedglycylamino)phenyl}-1,2,3-thiadiazoles (V) were prepared for evaluation of their antimicrobial activity. 4-chloroacetylaminoacetophenone (I) when reacted with different amines gave 4-glycylaminoacetophenone derivatives (II), Condensation of II with semicarbazide furnished the corresponding semicrabazones (III). Oxidative cyclization of (III) either by selenium dioxide or thionyl chloride afforded IV and V respectively.
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