INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS
Mulley, B., Aboutaleb, A., Abdel Rahman, A., Ahmed, S. (1986). INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS. EKB Journal Management System, 9(2), 157-171. doi: 10.21608/bfsa.1986.74587
B. A. Mulley; A. E. Aboutaleb; Aly A. Abdel Rahman; S. M. Ahmed. "INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS". EKB Journal Management System, 9, 2, 1986, 157-171. doi: 10.21608/bfsa.1986.74587
Mulley, B., Aboutaleb, A., Abdel Rahman, A., Ahmed, S. (1986). 'INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS', EKB Journal Management System, 9(2), pp. 157-171. doi: 10.21608/bfsa.1986.74587
Mulley, B., Aboutaleb, A., Abdel Rahman, A., Ahmed, S. INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS. EKB Journal Management System, 1986; 9(2): 157-171. doi: 10.21608/bfsa.1986.74587

INTERACTION OF 1,4-BENZODIAZEPINES WITH HYDROPHILIC MACROMOLECULES: V- WETTABILITY OF MODIFIED TEMAZEPAM CRYSTALS

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 9, Issue 2, December 1986, Page 157-171  XML PDF (459.5 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1986.74587
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Authors
B. A. Mulley1; A. E. Aboutaleb2; Aly A. Abdel Rahman2; S. M. Ahmed2
1School of Pharmacy, Bradford University, U.K
2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Wettability of temazepam crystals, crystallized from different concentrations of polysorbate 80 and cetomacrogol 1000 was evaluated quantitatively by measuring the contact angles on compressed discs of the crystallized drug. Increasing the concentration of the surfactant from which the drug was crystallized leads to increase in wettability. A direct correlation was found between the wettability of the drug and its dissolution.
An agreement was observed between the values of the contact angles measured using the adopted and the photographic methods.
The effect of time on the contact angle values was also investigated.
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