PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 12, Volume 9, Issue 2, December 1986, Page 172-186 PDF (412.65 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1986.74588 | ||||
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Authors | ||||
A. E. Aboutaleb; A. A. Abdel Rahman; M. O. Ahmed | ||||
Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
Abstract | ||||
Temazepam, a benzodiazepine derivative, was prepared in directly compressed tablets using Avicel, Anhydrous Lactose (A.H.L.), STA-Rx 1500, Emcompress and Compactrol. It was found that A.H.L. represents the most suitable single vehicle while Avicel : STA-RX 1:1 blend was the most suitable blend for the preparation of temazepam tablets. STA-RX 1500 and its blends with the other used vehicles were shown to give the highest dissolution. The most uniform tablets were produced on using Emcompress alone or as a binary blend with Avicel (1:1) as directly compressible vehicles. | ||||
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