Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients
El-Shahat, M., Hussein, N., Dala, A., Alghannam, O., El-Garawani, I. (2020). Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients. EKB Journal Management System, 2(1), 1-14. doi: 10.21608/jmals.2020.74592
Mohamed El-Shahat; Nasser Hussein; Ashraf Gharieb Dala; Osama Alghannam; Islam El-Garawani. "Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients". EKB Journal Management System, 2, 1, 2020, 1-14. doi: 10.21608/jmals.2020.74592
El-Shahat, M., Hussein, N., Dala, A., Alghannam, O., El-Garawani, I. (2020). 'Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients', EKB Journal Management System, 2(1), pp. 1-14. doi: 10.21608/jmals.2020.74592
El-Shahat, M., Hussein, N., Dala, A., Alghannam, O., El-Garawani, I. Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients. EKB Journal Management System, 2020; 2(1): 1-14. doi: 10.21608/jmals.2020.74592

Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients

Journal of Medical and Life Science
Article 1, Volume 2, Issue 1, March 2020, Page 1-14  XML PDF (641.76 K)
Document Type: Original Article
DOI: 10.21608/jmals.2020.74592
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Authors
Mohamed El-Shahat1; Nasser Hussein1; Ashraf Gharieb Dala2; Osama Alghannam1; Islam El-Garawani* 3
1Biochemistry and Molecular Biology Department, Genetic Engineering and Biotechnology Researches Institute (GEBRI), University of Sadat City, Egypt
2Department of Internal Medicine, Faculty of Medicine, Menoufia University
3Zoology Department, Faculty of Science, Menoufia University, Egypt
Abstract
The bone morphogenic protein-7 (BMP-7) gene is a member of the transforming growth factor-β (TGF-β) superfamily. BMP-7 is believed to act as a regulator of endogenous control of hepatocytes proliferation and liver homeostasis in adult hepatocytes. The present study aimed to assess the association of single nucleotide polymorphism (SNP), rs162316 (G>A), in BMP-7 gene with the progression of HCV or HBV- chronic liver cirrhosis to hepatocellular carcinoma (HCC). The tetra-primer amplification-refractory mutation system (ARMS-PCR) method was used for rs162316 genotyping. In this study, 150 subjects were divided into 50 healthy controls, 50 HCV or HBV-cirrhotic patients with HCC and 50 HCV or HBV-cirrhotic patients and HCC-free. Results of rs162316 genotyping revealed an association of SNP with 1.14 (0.64-2.03) and 1.43(0.79-2.58) alleles A frequencies (OR, CI 95%) in HCC patients compared to cirrhotic and healthy control groups respectively. For the specific studied SNP of BMP7 gene rs162316, the A allele (AG genotype) and was significantly associated with HCC progression. However, AG genotype of rs162316 may be considered as a predictor for HCC in Egyptian cirrhosis patients.
Keywords
Bone morphogenic protein-7; Single nucleotide polymorphism; Hepatocellular carcinoma; Liver cirrhosis
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