Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line
Ahmed, N., Alsulami, E., Badahdah, K., Al-Amshany, Z., Haiba, M. (2020). Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line. EKB Journal Management System, 63(10), 3757-3766. doi: 10.21608/ejchem.2020.24391.2451
Nesreen S. Ahmed; Eman S. Alsulami; Khadija O. Badahdah; Zahra M. Al-Amshany; Mogedda E. Haiba. "Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line". EKB Journal Management System, 63, 10, 2020, 3757-3766. doi: 10.21608/ejchem.2020.24391.2451
Ahmed, N., Alsulami, E., Badahdah, K., Al-Amshany, Z., Haiba, M. (2020). 'Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line', EKB Journal Management System, 63(10), pp. 3757-3766. doi: 10.21608/ejchem.2020.24391.2451
Ahmed, N., Alsulami, E., Badahdah, K., Al-Amshany, Z., Haiba, M. Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line. EKB Journal Management System, 2020; 63(10): 3757-3766. doi: 10.21608/ejchem.2020.24391.2451

Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line

Egyptian Journal of Chemistry
Article 15, Volume 63, Issue 10, October 2020, Page 3757-3766  XML PDF (705.84 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.24391.2451
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Authors
Nesreen S. Ahmed email orcid 1; Eman S. Alsulami2; Khadija O. Badahdah2; Zahra M. Al-Amshany2; Mogedda E. Haiba3
1Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Division, National Research Center,Cairo, Egypt
2Chemistry Dept., Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
3Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Center, El Buhouth Street, Dokki, Cairo, 12622, Egypt
Abstract
Abstract:
A new series of 2-phenyl-1,8-naphthyridine derivatives were synthesized via traditional heating and under ultrasonic irradiation to run out comparative study and confirm the utility of the green chemistry in organic synthesis. An improvement in the rates and yields were observed upon carrying out the reactions under environmentally benign protocol. The newly produced compounds were scanned in vitro for their adverse activity on HepG2 (Human liver) carcinoma cell lines. Results revealed that the tested compounds possess an inhibitory effect on the growth of HepG2 carcinoma cells. The naphthyridinyl pyridine derivatives 4c and 5c showed significant cytotoxic activity. The oxo-pyridine derivative4c was more potent than the reference drug doxorubicin (DOX), while the imino-pyridine derivative 5c showed slight reduction in the potency. On the other hand, Mannich bases (2a,c,d,e) showed good activity and the styryl derivatives (6b-d) showed moderate activity when compared to (DOX).
Keywords
ultrasound irradiations; 1,8-naphthyridine; mannich bases; styryl compounds; Pyridine; cytotoxic
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