SALIVARY INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 AND TRANSFERRIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA VERSUS ORAL LICHEN PLANUS
Elwakeel, N., Shaker, O. (2017). SALIVARY INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 AND TRANSFERRIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA VERSUS ORAL LICHEN PLANUS. EKB Journal Management System, 63(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 579-589. doi: 10.21608/edj.2017.75007
Naglaa M. Elwakeel; Olfat G. Shaker. "SALIVARY INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 AND TRANSFERRIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA VERSUS ORAL LICHEN PLANUS". EKB Journal Management System, 63, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2017, 579-589. doi: 10.21608/edj.2017.75007
Elwakeel, N., Shaker, O. (2017). 'SALIVARY INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 AND TRANSFERRIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA VERSUS ORAL LICHEN PLANUS', EKB Journal Management System, 63(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 579-589. doi: 10.21608/edj.2017.75007
Elwakeel, N., Shaker, O. SALIVARY INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 AND TRANSFERRIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA VERSUS ORAL LICHEN PLANUS. EKB Journal Management System, 2017; 63(Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 579-589. doi: 10.21608/edj.2017.75007

SALIVARY INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-3 AND TRANSFERRIN LEVELS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA VERSUS ORAL LICHEN PLANUS

Egyptian Dental Journal
Article 13, Volume 63, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), January 2017, Page 579-589  XML PDF (295.08 K)
Document Type: Original Article
DOI: 10.21608/edj.2017.75007
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Authors
Naglaa M. Elwakeel1; Olfat G. Shaker2
1Oral Medicine, Diagnosis, Periodontology and Radiology, Faculty of Dental Medicine, Al Azhar University (Girls Branch), Cairo, Egypt; Oral Medicine, Diagnosis, Periodontology, Faculty of Dentistry, MSA University, Giza, Egypt.
2Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract
Objective: To gather preliminary data concerning local salivary levels of insulin like growth factor binding protein-3 (IGFBP-3) and its binding protein transferrin (Tf) in patients suffering from oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP) compared to normal controls and to correlate it with clinical picture in OLp and histologic grading in OSCC.
Materials and methods: Salivary samples from 40 patients suffering from OSCC (20 poorly and 20 moderately differentiated), 40 patients suffering from OLP (clinically evaluated using REU scoring system) and 40 controls were collected and TF and IGFbP-3 levels were estimated using enzyme linked immunosorbent assay (ELISA), for statistical analysis, ANOVA followed by Tukey’s post hoc and Pearson correlation tests were used.
Results: Significantly higher salivary levels of IGFBP-3 and Tf were recorded in different histological grades of SCC in comparison to Olp. Control group recorded the lowest significant values compared to OLP and OSCC (p<0.0001). A week positive correlation was recorded between levels of Tf and IGFBP-3 in all groups. As well, a week positive correlation between IGFBP-3 and Tf levels with REU in OLP and histological grades in OSCC was shown, except for the correlation between TF and OSCC histologic grading that was strong positive.
Conclusions: IGFBP-3 and Tf seems to play a role in pathogenesis of both OSCC and Olp, and could be considered as a reliable marker in diagnosis of OSCC and OLP, However, further studies are required .
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