Outcome of Methotrexate Therapy in The Management of Undisturbed Tubal Ectopic Pregnancy
Gharib, M., mohamed, M., El-Nagar, W., El-sayed, A. (2022). Outcome of Methotrexate Therapy in The Management of Undisturbed Tubal Ectopic Pregnancy. EKB Journal Management System, 28(5), 1075-1079. doi: 10.21608/zumj.2020.21948.1690
Mahmoud Ahmed Gharib; mohamed lotfy mohamed; Walid Mohamed El-Nagar; Amira El-sayed. "Outcome of Methotrexate Therapy in The Management of Undisturbed Tubal Ectopic Pregnancy". EKB Journal Management System, 28, 5, 2022, 1075-1079. doi: 10.21608/zumj.2020.21948.1690
Gharib, M., mohamed, M., El-Nagar, W., El-sayed, A. (2022). 'Outcome of Methotrexate Therapy in The Management of Undisturbed Tubal Ectopic Pregnancy', EKB Journal Management System, 28(5), pp. 1075-1079. doi: 10.21608/zumj.2020.21948.1690
Gharib, M., mohamed, M., El-Nagar, W., El-sayed, A. Outcome of Methotrexate Therapy in The Management of Undisturbed Tubal Ectopic Pregnancy. EKB Journal Management System, 2022; 28(5): 1075-1079. doi: 10.21608/zumj.2020.21948.1690

Outcome of Methotrexate Therapy in The Management of Undisturbed Tubal Ectopic Pregnancy

Zagazig University Medical Journal
Article 22, Volume 28, Issue 5, September 2022, Page 1075-1079  XML PDF (418.25 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.21948.1690
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Authors
Mahmoud Ahmed Gharib1; mohamed lotfy mohamed2; Walid Mohamed El-Nagar1; Amira El-sayed email 3
1Department of Obstetrics and Gynecology, Faculty of Medicine ,Zagazig University, Zagazig, Egypt
2obstetric and gynecology department,faculty of medicine ,zagazig university Zagazig ,Egypt
3Obstetric and gynecology department,faculty of medicine, zagazig university zagazig , Egypt
Abstract
Abstract
Abstract
Background: Ectopic pregnancy (EP) is implantation of the fertilized egg 5 outside endometrial cavity of uterus. Diagnosis of an ectopic pregnancy is vital , 6 as it can save mother’s life before tubal rupture takes place . Tubal rupture accounts 7 for 6% of deaths related to pregnancy . Ectopic pregnancy is treated either by 8 expectant management , methotrexate or surgical treatment. Objectives: in this study 9 we assess the association between using of Methotrexate and cure of undisturbed 10 tubal ectopic pregnancy .Methods: a clinical trial was performed on 16 patients with 11 undisturbed tubal ectopic pregnancy . Patients are given I.M methotrexate by a 12 dose of 1 mg/kg or Body Surface Area (BSA) dose based of 50mg/m2 and follow 13 up of the outcome either cure , laparoscopy or laparotomy. Results: There are 14 statistically non-significant differences between responder and non-responder 15 regarding age , BMI, gravidity, mass position, parity, history of abortion, gestational 16 age and mode of delivery .Alsowe found that by the end of the first week after 17 methotrexate intake, the decline in β-hCG was statistically significant among 18 responders (p value =0.001) while non-responders show non-significant change(p 19 value = 0.120 ).we also found that 11patients respond to methotrexate therapy 20 (68.7% ) while the remaining 5 patients were non responders .Conclusion: We 21 concluded that Methotrexate is an effective medical management for an ectopic 22 pregnancy especially when conservation of fallopian tube is needed .
Keywords
Key words: undisturbed; tubal; ectopic; Pregnancy; Methotrexate
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