Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging
altantawy, N., sherief, L., Ahmed Ali, A., Gaber, O. (2022). Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging. EKB Journal Management System, 28(3), 526-533. doi: 10.21608/zumj.2020.22066.1677
nesma altantawy; laila metwaly sherief; AL Shaymaa Ahmed Ahmed Ali; Osama AbdelAziz Gaber. "Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging". EKB Journal Management System, 28, 3, 2022, 526-533. doi: 10.21608/zumj.2020.22066.1677
altantawy, N., sherief, L., Ahmed Ali, A., Gaber, O. (2022). 'Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging', EKB Journal Management System, 28(3), pp. 526-533. doi: 10.21608/zumj.2020.22066.1677
altantawy, N., sherief, L., Ahmed Ali, A., Gaber, O. Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging. EKB Journal Management System, 2022; 28(3): 526-533. doi: 10.21608/zumj.2020.22066.1677

Assessment of cardiotoxicity in survivors of Acute Lymphoblastic Leukemia by Tissue Doppler imaging

Zagazig University Medical Journal
Article 18, Volume 28, Issue 3, May 2022, Page 526-533  XML PDF (508.59 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.22066.1677
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Authors
nesma altantawy email 1; laila metwaly sherief2; AL Shaymaa Ahmed Ahmed Ali3; Osama AbdelAziz Gaber4
1pediatric department Mit Ghamr hospital Dakahleia governrate Egypt
21.Pediatric Hematology and Oncology –Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
3Department of Pediatrics Faculty of Medicine – Zagazig University, Egypt
4Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
ABSTRACT
Background: Cardiotoxicity development in survivors of acute lymphoblastic leukemia is one of the most serious chronic complications of cancer therapy. Objectives: This study aimed to assess the frequency of doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia. Methods: We utilized a cross section case-control study design and included 50 ALL survivors attending pediatric oncology clinic for follow up after finishing chemotherapy and 50 age- and sex-matched controls. All participants were subjected to full general examination. The cardiac status was assessed by Echocardiography and Tissue Doppler Technique.Results:. Tissue doppler parameters S" (myocardial systolic velocity) m/sec, E" (early phase of diastole negative velocity) and A” m/sec (late phase of diastole negative velocity) , A (peak early mitral inflow velocity) and E (peak late mitral inflow velocity) wave DT(deceleration time) ,GCS(global circumferential strain) &GLS(global longtudinal strain) were statistically lower among ALL survivor, than controls,but MPI(myocardial performance index) was statistically higher among ALL survivor than controls.
Conclusion: Our results demonstrated that all echocardiographic and Tissue Doppler parameters are lower among ALL survivors than controls, except that MPI(myocardial performance index) , LVED (left ventricular end diastolic dimention) and LVES(left ventricular end systolic dimention) is higher among ALL survivors than controls indicating cardiac dysfunction among ALL survivors.
Keywords
Doxorubicin; ALL survivors; cardiotoxicity
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