Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES
ABD EL-GHAFFAR, N., KADAH, M., RADWAN, A., ABD EL-AL, S., SALMAN, A. (2009). Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES. EKB Journal Management System, 20(Issue 1-A), 91-101. doi: 10.21608/absb.2009.7546
NAHED F. ABD EL-GHAFFAR; MONA S. KADAH; AZZA M. RADWAN; SARA N. ABD EL-AL; ASMAA S. SALMAN. "Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES". EKB Journal Management System, 20, Issue 1-A, 2009, 91-101. doi: 10.21608/absb.2009.7546
ABD EL-GHAFFAR, N., KADAH, M., RADWAN, A., ABD EL-AL, S., SALMAN, A. (2009). 'Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES', EKB Journal Management System, 20(Issue 1-A), pp. 91-101. doi: 10.21608/absb.2009.7546
ABD EL-GHAFFAR, N., KADAH, M., RADWAN, A., ABD EL-AL, S., SALMAN, A. Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES. EKB Journal Management System, 2009; 20(Issue 1-A): 91-101. doi: 10.21608/absb.2009.7546

Part 1: SYNTHESIS AND REACTIONS OF SOME NEW PYRAZOLO[4,5-D]IMIDAZOLE DERIVATIVES AND SCREENING THEIR ANTIBACTERIAL AND ANTITUMOR ACTIVITIES

Al-Azhar Bulletin of Science
Article 8, Volume 20, Issue 1-A, June 2009, Page 91-101  XML PDF (133.54 K)
Document Type: Original Article
DOI: 10.21608/absb.2009.7546
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Authors
NAHED F. ABD EL-GHAFFAR; MONA S. KADAH* ; AZZA M. RADWAN; SARA N. ABD EL-AL; ASMAA S. SALMAN
Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.
Abstract
Reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with diazotized aromatic amines gave the corresponding diazenyl derivatives 1, which were condensed with carbonyl compounds to give the arylidene derivatives 2. Reaction of the parent pyrazolone with urea, thiourea and guanidine gave the pyrazoloimidazole derivatives 3. compound 3a reacted with thiourea in DMF to give the thiourea derivative 4. The reaction of 4 with malonic acid and acetyl chloride gave the pyrimidinedione derivative 5, which on reaction with thiourea in presence of sodium ethoxide gave the triazine derivative 6. S-alkylation of 6 with ethyl chloroacetate gave the ethyl acetate derivative 7, which on hydrolysis gave the corresponding acid, derivative8 and on reaction with hydrazine hydrate gave the corresponding acetohydrazide 9. the reaction of compound 9 with salicylaldehyde gave the pynazolidinone 10, while with carbon disulphide in alkaline solution it gave the oxadiazole thione 11 respectively. Some of the new compounds showed antimicrobial and antitumor activities.
Keywords
Pyrazoloimidazole; pyrimidinedione; triazine; Antimicrobial; antitumor
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