Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES
KADAH, M., ABD EL-GHAFFAR, N., RADWAN, A., ABD EL-AL, S., SALMAN, A. (2009). Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES. EKB Journal Management System, 20(Issue 1-A), 102-111. doi: 10.21608/absb.2009.7547
MONA S. KADAH; NAHED F. ABD EL-GHAFFAR; AZZA M. RADWAN; SARA N. ABD EL-AL; ASMAA S. SALMAN. "Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES". EKB Journal Management System, 20, Issue 1-A, 2009, 102-111. doi: 10.21608/absb.2009.7547
KADAH, M., ABD EL-GHAFFAR, N., RADWAN, A., ABD EL-AL, S., SALMAN, A. (2009). 'Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES', EKB Journal Management System, 20(Issue 1-A), pp. 102-111. doi: 10.21608/absb.2009.7547
KADAH, M., ABD EL-GHAFFAR, N., RADWAN, A., ABD EL-AL, S., SALMAN, A. Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES. EKB Journal Management System, 2009; 20(Issue 1-A): 102-111. doi: 10.21608/absb.2009.7547

Part 2: SYNTHESIS AND REACTIONS OF SOME NEW IMIDAZO[4,5-C]PYRAZOLE AND PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES

Al-Azhar Bulletin of Science
Article 9, Volume 20, Issue 1-A, June 2009, Page 102-111  XML PDF (120.89 K)
Document Type: Original Article
DOI: 10.21608/absb.2009.7547
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Authors
MONA S. KADAH* ; NAHED F. ABD EL-GHAFFAR* ; AZZA M. RADWAN; SARA N. ABD EL-AL; ASMAA S. SALMAN
Chemistry Department, Faculty of Science (GIRLS), Al -Azhar University, Cairo, Egypt.
Abstract
Reactions of 3-methyl-1-phenyl-4,6-dihydroimidazo[4,5-c]pyrazole-5(1H)-thione with carbonyl compounds gave the arylidene derivatives 2 and 3, with recinoleic acid, phosphorus oxychloride/phosphorus pentachloride mixture and copper bronze gave the adduct 4, the chloro derivative 5 and the dimer with desulfurization 7. The behaviour of the chloroderivative towards hydrazine and primary amines have also been studied. On the other, reaction of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one with aromatic aldehydes gave the arylidene derivatives 8a-d, which on reaction with thiourea gave the pyrazolopyrimidinethione derivatives 9. The behaviour of compounds 9 towards copper bronze, sodium nitrite/acetic acid mixture, acrylonitrile and formaldehyde/ morpholine and its reaction with compound 1 in presence of copper bronze have also been taken into consideration.
Keywords
Pyrazoloimidazole; pyrazolopyrimidine; pyrazolone
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