SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST
TAHA, N., ISLAM, E., MARZOK, N., ELATRASH, A., MICKY, J. (2009). SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST. EKB Journal Management System, 20(Issue 1-A), 125-138. doi: 10.21608/absb.2009.7549
NADIA M. TAHA; ENAS ISLAM; NERMIN A. MARZOK; ABEER M. ELATRASH; JEHANE A. MICKY. "SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST". EKB Journal Management System, 20, Issue 1-A, 2009, 125-138. doi: 10.21608/absb.2009.7549
TAHA, N., ISLAM, E., MARZOK, N., ELATRASH, A., MICKY, J. (2009). 'SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST', EKB Journal Management System, 20(Issue 1-A), pp. 125-138. doi: 10.21608/absb.2009.7549
TAHA, N., ISLAM, E., MARZOK, N., ELATRASH, A., MICKY, J. SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST. EKB Journal Management System, 2009; 20(Issue 1-A): 125-138. doi: 10.21608/absb.2009.7549

SYNTHESIS OF SOME BENZOFURANYL THIENO[2,3-D] PYRIMIDINE DERIVATIVES WITH BIOLOGICAL INTEREST

Al-Azhar Bulletin of Science
Article 11, Volume 20, Issue 1-A, June 2009, Page 125-138  XML PDF (121.21 K)
Document Type: Original Article
DOI: 10.21608/absb.2009.7549
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Authors
NADIA M. TAHA* ; ENAS ISLAM; NERMIN A. MARZOK; ABEER M. ELATRASH; JEHANE A. MICKY
Chemistry Department, Al-Azhar University (Girls), Faculty of Science, Cairo, Egypt.
Abstract
Interaction of visnaginone or khellinone (1a,b) with cyanoacetamide, ethyl cyanoacetate or molanonitrile and elemental sulfur in presence of triethylamine afforded thiophene enamino derivatives (2a-d) respectively according to Gewald method. Acetylation of 2a with acetic anhydride gave 3. Condensation of 2b with p-chlorobenzaldehyde yielded 4. Compound 6 was afforded from reaction of enamino carboxamide (2b) with thiourea.. Compound 2b reacted with benzoyl chloride to give thienopyrimidine (8). N-phenyl thienopyrimidine (11) and N-amino thienopyrimidine (13) were prepared from reaction of 2c with phenyl isothiocyanate and hydrazinolysis of 12 with hydrazine hydrate.
The structures of these compounds were confirmed by infrared, mass and 1H-NMR spectra. The biological activity of some compounds were discussed and found to be active.
Keywords
BENZOFURANYL THIENO[2,3-D]; pyrimidine derivatives
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