A CAST FILM APPROACH TO THE STUDY OF IN-VITRO DRUG RELEASE FROM OINTMENTS AND CREAMS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 8, Issue 2, December 1985, Page 12-24 PDF (332.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1985.75892 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ahmed T. Nouh; Esmat Z. El-Deen; M. H. Hanaa Mahmoud | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| The release rate of Nystation from a casted film of Amphocerin-E and Dehymuls-K ointment bases was investigated. The role of surfactants in enhancing the drug release was also studied. The rate of release of the drug from Dehymuls-K was found markedly higher than that of Amphocerin-E. The surfactants used markedly increase the release rate of the drug from the bases. Sodium lauryl sulfate, whether present in the casted film base or in the aqueous release medium enhances the rate of release of Nystation when compared to cetrimide. The effect of surfactant is more pronounced if it was added to the release medium than when incorporated in the casted base film. Higuchi model was applied for all experimental release data, where a good correlation was observed. | ||||
|
Statistics Article View: 67 PDF Download: 133 |
||||
