EVALUATION AND BIOAVAILABILITY OF PHENAZOPYRIDINE HYDROCHLORIDE TABLETS PREPARED WITH COMPACTROL | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 6, Volume 8, Issue 2, December 1985, Page 88-103 PDF (389.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1985.75897 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Hamdy M. Abdel-Aleem; Mohamed H. Elshaboury; Abdel-Gawad H. Abdel-Gawad | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Phenazopyridine hydrochloride tablets were prepared at different packing fractions using the newly introduced direct compressible vehicle "compactrol". Tablets were also prepared with avicel and wet granulation technique for comparison. The physical standards and dissolution rate of the produced tablets were investigated. Also the In-Vivo study for tablets having the highest mechanical strength was carried out. The results revealed that increasing the packing fraction was followed by an increase in tablet hardness and a decrease in friability percent. Also the disintegration time for tablets prepared by wet granulation technique was increased. However, the dissolution rate of all the produced tablets was slightly affected by the increase in the packing fraction. Compactrol produced the hardest tablets (6 Kg), of the shortest disintegration time (0.17 min.). As regards the bioavailability, avicel produced tablets with the highest bioavailability. On the other hand, the bioavailability of tablets prepared with compactrol and wet granulation was similar. Thus, phenazopyridine tablets can be prepared by direct compression technique to ensure highest mechanical strength and highest bioavailability. | ||||
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