SPECTROPHOTOMETRIC DETERMINATION OF NITRAZEPAM IN TABLETS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 8, Issue 2, December 1985, Page 134-142 PDF (824 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1985.75900 | ||||
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| Author | ||||
| Salwa Rizk El-Shabouri | ||||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| A sensitive spectrophotometric method is reported for the determination of nitrazepam either pure or in tablets. The method is based on the reduction of nitrazepam with zinc dust and calcium chloride followed by reacting the reduced compound with trisodium pentacyanoaminoferrate. The reaction gives a violet product having an absorbance maximum at 560 nm. Beer's law is obeyed in the concentration range of 25-500 mg/ml of the reaction mixture. The common excipients in tablets do not interfere. The recovery and precision are similar to those of the official B.P. method. | ||||
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