INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES
Mulley, B., Aboutaleb, A., Abdel Rahman, A., Ahmed, S. (1985). INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES. EKB Journal Management System, 8(2), 171-185. doi: 10.21608/bfsa.1985.75903
B. A. Mulley; A. E. Aboutaleb; Aly A. Abdel Rahman; S. M. Ahmed. "INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES". EKB Journal Management System, 8, 2, 1985, 171-185. doi: 10.21608/bfsa.1985.75903
Mulley, B., Aboutaleb, A., Abdel Rahman, A., Ahmed, S. (1985). 'INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES', EKB Journal Management System, 8(2), pp. 171-185. doi: 10.21608/bfsa.1985.75903
Mulley, B., Aboutaleb, A., Abdel Rahman, A., Ahmed, S. INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES. EKB Journal Management System, 1985; 8(2): 171-185. doi: 10.21608/bfsa.1985.75903

INTERACTION OF 1,4-BENZODIAZEPINES WITH CERTAIN MACROMOLECULES: II- CRYSTALLIZATION OF TEMAZEPAM IN PRESENCE OF HYDROPHILIC MACROMOLECULES

Bulletin of Pharmaceutical Sciences Assiut University
Article 12, Volume 8, Issue 2, December 1985, Page 171-185  XML PDF (439.38 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1985.75903
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Authors
B. A. Mulley1; A. E. Aboutaleb2; Aly A. Abdel Rahman2; S. M. Ahmed3
1School of Pharmacy, Bradford University, England
2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
3Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt and School of Pharmacy, Bradford University, England
Abstract
Temazepam was crystallized from either ethanol or ethanol containing different concentrations of polysorbate 80, cetomacrogol 1000, Myrj 52 and PVP 40000 at 50°C. The produced treated crystals, as well as the untreated ones were subjected to solubility and computerized thermal studies, electron scanning microscopic examinations, determination of drug content and dissolution rates using particulate and intrinsic dissolution methods and employing recycling and automatic recording systems.
Crystallization of the investigated drug from ethanol containing the afore-mentioned additives enhanced the dissolution rate to a varying extent, as demonstrated by a decrease in the T50% and the increase in the R.D.R. Decreasing the concentration of cetomacrogol 1000 and polysorbate 80 in the crystallization medium causes a gradual drop in dissolution rates.
Thermal analysis of the produced crystals revealed a negligible change in melting points and a slight change in the enthalpy of fusion (DHf).
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