ANTICANCER EFFECT OF SALVIA (MARAMIA) EXTRACT ON HEP-2 CANCER CELL LINE | ||||
| Egyptian Dental Journal | ||||
| Article 10, Volume 63, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2017, Page 3253-3261 PDF (391.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2017.76178 | ||||
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| Authors | ||||
| Ahmed Nabil Fahmi1; Amr H. Elbolok2; Naglaa M. Kamal3 | ||||
| 1Lecturer, Oral Pathology Department, Faculty of Oral and Dental Medicine, BeniSuef University, Egypt. | ||||
| 2Associate professor, Oral Pathology Department, Faculty of Oral and Dental Medicine, Minia University, Egypt. | ||||
| 3Lecturer, Oral Pathology Department, Faculty of Oral and Dental Medicine, Ahram Canadian University, 6 October City, Giza Egypt. th of | ||||
| Abstract | ||||
| Sage (salvia) species have been used for a long time to relief pain; protect the body against viral and bacterial infection and inflammation, treatment of life‑threatening diseases as heart disease, diabetes, and cancer. Many studies advocated sage species for drug development because of their recorded therapeutic effects including anti-proliferative and cytotoxic effects against malignant cells. Objective: Evaluate the anticancer effect of salvia extract. Materials and Methods: A pure extracts from ground leaves of salvia were added to nasopharyngeal carcinoma cell line and to normal cell line as a control. Results: Anti-proliferative effects of Salvia showed the highest cytotoxic effect against nasopharyngeal carcinoma cell line after 28 h of influence. We observed no anti-proliferative effects on the healthy cell line. Conclusions: Our results confirmed the potent genotoxic and anti-proliferative properties of Salvia against laryngeal cancer cell line. | ||||
| Keywords | ||||
| Sage (Salvia species); Cancer; apoptosis; cell line; Essential oils | ||||
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