INCREASED SALIVARY AND SERUM LEVELS OF IL-33 IN PATIENTS WITH ORAL PEMPHIGUS VULGARIS | ||||
| Egyptian Dental Journal | ||||
| Article 15, Volume 63, Issue 4 - October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), October 2017, Page 3301-3307 PDF (372.75 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2017.76186 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Gihane Gharib Madkour1; Ibrahim EL Refaie2 | ||||
| 1Associate Professor of Oral Medicine, Diagnosis and Periodontology, Faculty of Oral and Dental Medicine, Cairo University, Egypt. | ||||
| 2Lecturer of Oral Medicine, Diagnosis and Periodontology, Faculty of Oral and Dental Medicine, Cairo University, Egypt | ||||
| Abstract | ||||
| Objective: The objective of this study was to investigate salivary and serum levels of IL-33 in oral pemphigus vulgaris patients, before and after corticosteroid therapy, in a trial to elucidate its possible role in the disease pathogenesis. Subjects and Methods: This study included 30 individuals; 15 patients with oral pemphigus vulgaris and 15 healthy controls. Salivary and serum samples were collected from all patients, before and after corticosteroid therapy, and form healthy controls. IL-33 was quantified in all salivary and serum samples utilizing enzyme-linked immunosorbent assay (ELISA). Results: Compared to healthy controls, IL-33 levels were statistically significantly higher in saliva and serum of patients with oral pemphigus vulgaris. Salivary and serum Levels of IL-33 decreased significantly in all patients after corticosteroid therapy. Conclusion: Results of this study suggest that IL-33 may have a key role in oral pemphigus vulgaris pathogenesis. IL-33 may become a new therapeutic target for oral pemphigus vulgaris. | ||||
| Keywords | ||||
| Oral Pemphigus vulgaris; IL-33; saliva; serum | ||||
|
Statistics Article View: 107 PDF Download: 194 |
||||
