Spectrophotometric Method for Indirect Determination Of Antihypertensive Drugs in Pharmaceuticals | ||||
| Egyptian Journal of Chemistry | ||||
| Article 16, Volume 63, Issue 10, October 2020, Page 3767-3777 PDF (1.24 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2020.18096.2102 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohammed yahya dhamra  ; Theia'a Najim Al-Sabha
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| Chemistry Department, College of Education for Pure Science, Mosul University,Iraq | ||||
| Abstract | ||||
| Abstract A spectrophotometric method is proposed for the determination of antihypertensive drugs namely Propranolol and Methyldopa in their pure forms and in pharmaceutical formulations, based on the oxidation of the drugs with an excess of N-Bromo succinimide and the residual oxidizing agent bleaches the red colored eriochrom black-T (EBT) which is measured at 530 nm at room temperature. Linear calibration graphs were obtained in the concentration range 0.1-10 and 0.1-9 μg ml-1 with molar absorptivity 6.06×104 and 4.60×104 L.mol-1.cm-1 for above drugs respectively. No interference was observed coexistent substance. The proposed method was applied successfully for the determination of the drugs in their pharmaceutical formulations. | ||||
| Keywords | ||||
| Keywords: Spectrophotometry; EBT; Antihypertensive drugs | ||||
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