EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS
AMER, M., ABDEL KHALIK, M., KHEDR, M., MASSOUD, S. (2018). EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS. EKB Journal Management System, 48(3), 583-586. doi: 10.21608/jesp.2018.76567
MOHIE ELDIN AMER; MOHAMED ABDEL RASHEED ABDEL KHALIK; MOHAMED ABDEL HAMMID BASSYONI KHEDR; SAFWAT AHMED MOHAMED ALI MASSOUD. "EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS". EKB Journal Management System, 48, 3, 2018, 583-586. doi: 10.21608/jesp.2018.76567
AMER, M., ABDEL KHALIK, M., KHEDR, M., MASSOUD, S. (2018). 'EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS', EKB Journal Management System, 48(3), pp. 583-586. doi: 10.21608/jesp.2018.76567
AMER, M., ABDEL KHALIK, M., KHEDR, M., MASSOUD, S. EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS. EKB Journal Management System, 2018; 48(3): 583-586. doi: 10.21608/jesp.2018.76567

EFFECT OF HELICOBACTER PYLORI ERADICATIONON THE PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY IN EGYPTIAN PATIENTS WITH LIVER CIRRHOSIS

Journal of the Egyptian Society of Parasitology
Article 13, Volume 48, Issue 3, December 2018, Page 583-586  XML PDF (375.28 K)
Document Type: Original Article
DOI: 10.21608/jesp.2018.76567
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Authors
MOHIE ELDIN AMER1; MOHAMED ABDEL RASHEED ABDEL KHALIK1; MOHAMED ABDEL HAMMID BASSYONI KHEDR2; SAFWAT AHMED MOHAMED ALI MASSOUD3
1Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
2Department of Clinical Pathology2, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
3Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Abstract
Hepatic encephalopathy is one of the complications of liver cirrhosis. Ammonia is implicated as a precipitating factor for HE, minimal hepatic encephalopathy cannot be detected clinically and impairs quality of life, indicated that H. pylori infection is associated with high blood ammonia levels by urease enzyme and can lead to causation of HE. This study evaluated the effect of H. pylori eradication therapy on MHE. A total of 60 cirrhotic patients were selected from al-Hussein University Hospital. They were GI: 30 patients with MHE and GII; 30 patients without MHE. All patients were subjected to H. pylori stool antigen and blood ammonia level. Positive H. pylori patients received triple therapy for 14 days, then 4 weeks later were revaluated regarding, H. pylori stool antigen, serum ammonia level and NCT. Helicobacter pylori infection was found 63.3% of GI versus 40% in GII; serum ammonia levels were significantly higher in patients with GI and H. pylori positive. Treatment was successful in 78.9% of GI patients versus 89.4% of GII. Number connection test and serum ammonia level were significantly improved in GI patients and positive H. pylori after eradication therapy.
Keywords
Egypt; Minimal hepatic encephalopathy; Serum ammonia; Helicobacter pylori
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