The potential role of CD31 and Bcl-2 in the etiopathogenesis of oral pyogenic granuloma | ||||
| Egyptian Dental Journal | ||||
| Article 4, Volume 64, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2018, Page 2131-2140 PDF (1.89 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2018.76771 | ||||
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| Author | ||||
| Naglaa M. Kamal | ||||
| Lecturer, Oral Pathology Department, Faculty of Oral and Dental Medicine, Ahram Canadian University, 6th of October City, Giza Egypt | ||||
| Abstract | ||||
| Pyogenic granuloma (PG) is a vascular reactive lesion of the oral cavity which is caused by local trauma or irritation and has a distinct biological behavior. Up till now, the pathogenesis of PG is not adequately understood. Aim: Assessment of the expression of CD31 and Bcl-2 in PG to clarify the etiopathogenesis of this lesion and to determine whether vascular proliferation in this lesion has a relation to its apoptotic status. Materials and Methods: 4μm sections were prepared from paraffin-embedded blocks of PG (20 samples) and normal gingiva as a control (10 samples). Staining of each specimen with hematoxylin and eosin (H&E), CD31 and Bcl-2 was done. Results: all lesions of PG showed positive CD31 and Bcl-2 immunostaining in the endothelial cells of blood vessels and in the stromal ovoid cells. Control group showed positive CD31expression in the endothelial cells of blood vessels while Bcl-2 expression revealed positive expression mainly in the basal cells of the epithelium. A significant higher expression of CD31 and Bcl-2 was detected in PG than normal gingiva. A strong positive correlation was found between CD31 and Bcl-2 area percent of immune-expression. Conclusions: The data of the present study suggest a role of Bcl-2 overexpression in the potentiation of angiogenic response and support the role of CD31 and Bcl-2 in the etiopathogenesis of PG. | ||||
| Keywords | ||||
| Pyogenic Granuloma; CD31; Bcl-2; Immunohistochemistry | ||||
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