Evaluation of leptin levels in the serum and gingival cevicular fluid of chronic periodontitis patients
Salem, A., Al-Harthi, N., Dardir, A., Youssef, A. (2018). Evaluation of leptin levels in the serum and gingival cevicular fluid of chronic periodontitis patients. EKB Journal Management System, 64(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 2155-2159. doi: 10.21608/edj.2018.76779
Ali Salem; Naif Al-Harthi; Ahmed Dardir; Abdel-Rahman Youssef. "Evaluation of leptin levels in the serum and gingival cevicular fluid of chronic periodontitis patients". EKB Journal Management System, 64, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2018, 2155-2159. doi: 10.21608/edj.2018.76779
Salem, A., Al-Harthi, N., Dardir, A., Youssef, A. (2018). 'Evaluation of leptin levels in the serum and gingival cevicular fluid of chronic periodontitis patients', EKB Journal Management System, 64(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 2155-2159. doi: 10.21608/edj.2018.76779
Salem, A., Al-Harthi, N., Dardir, A., Youssef, A. Evaluation of leptin levels in the serum and gingival cevicular fluid of chronic periodontitis patients. EKB Journal Management System, 2018; 64(Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 2155-2159. doi: 10.21608/edj.2018.76779

Evaluation of leptin levels in the serum and gingival cevicular fluid of chronic periodontitis patients

Egyptian Dental Journal
Article 6, Volume 64, Issue 3 - July (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), July 2018, Page 2155-2159  XML PDF (302.78 K)
Document Type: Original Article
DOI: 10.21608/edj.2018.76779
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Authors
Ali Salem1; Naif Al-Harthi1; Ahmed Dardir2; Abdel-Rahman Youssef3
1Dental intern Practitioner, Faculty of Dentistry, Umm Al-Qura University, KSA
2Assistant Professor of Periodontology, Department of Oral Medicine and Periodontology, Ahram Canadian University, Egypt and Umm Al-Qura University, KSA.
3Assistant Professor of Microbiology and Immunology, Faculty of Medicine, Umm Al-Qura University, Saudi Arabia and Suez Canal University Egypt.
Abstract
Leptin is pro-inflammatory mediator associated with the pathogenesis of periodontitis. The objective of the current study was to assess the levels of leptin in serum and gingival crevicular fluid (GCF) in chronic periodontitis (CP) patients. This cross-sectional study was conducted in Dental Teaching Hospital, Umm Al-Qura University, Makkah, Saudi Arabia. Forty-five individuals participated in this study: 25 with chronic periodontitis patients and 20 periodontally healthy controls. The patients were selected based on the criteria of American Academy of Periodontology using probing depths, bleeding on probing, clinical attachment loss and radiographs. GCF and serum samples were collected to estimate the leptin concentrations using enzyme-linked immunosorbent assay kits. Serum leptin levels were markedly higher in chronic periodontitis patients than in the healthy group (P < 0.00001). Although GCF leptin levels of chronic periodontitis patients were higher than the healthy group but this difference was not statistically significant (P Value = 0.5198). In conclusion, these results indicate positive association between serum leptin concentrations and chronic periodontitis. However, there was no significant correlation between GCF leptin level and periodontitis. Further studies are required to confirm these finding.
Keywords
leptin; Chronic Periodontitis; gingival crevicular fluid; serum
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