Hormonal and Immunological responses to Coleus forskohlii treatment in Female Rats with Experimentally Polycystic Ovaries Syndrome
Abd-Allah, H., AbdAlhady, M., Abdelall, M., Mohamedy, S., Alharbi, W., Bahathiq, A. (2017). Hormonal and Immunological responses to Coleus forskohlii treatment in Female Rats with Experimentally Polycystic Ovaries Syndrome. EKB Journal Management System, 45(1), 74-81. doi: 10.21608/zvjz.2017.7689
Hoda Abd-Allah; Mona M. AbdAlhady; Magda N.A. Abdelall; Sahar N. Mohamedy; Waheeb D.M. Alharbi; Adil O. Bahathiq. "Hormonal and Immunological responses to Coleus forskohlii treatment in Female Rats with Experimentally Polycystic Ovaries Syndrome". EKB Journal Management System, 45, 1, 2017, 74-81. doi: 10.21608/zvjz.2017.7689
Abd-Allah, H., AbdAlhady, M., Abdelall, M., Mohamedy, S., Alharbi, W., Bahathiq, A. (2017). 'Hormonal and Immunological responses to Coleus forskohlii treatment in Female Rats with Experimentally Polycystic Ovaries Syndrome', EKB Journal Management System, 45(1), pp. 74-81. doi: 10.21608/zvjz.2017.7689
Abd-Allah, H., AbdAlhady, M., Abdelall, M., Mohamedy, S., Alharbi, W., Bahathiq, A. Hormonal and Immunological responses to Coleus forskohlii treatment in Female Rats with Experimentally Polycystic Ovaries Syndrome. EKB Journal Management System, 2017; 45(1): 74-81. doi: 10.21608/zvjz.2017.7689

Hormonal and Immunological responses to Coleus forskohlii treatment in Female Rats with Experimentally Polycystic Ovaries Syndrome

Zagazig Veterinary Journal
Article 9, Volume 45, Issue 1, March 2017, Page 74-81  XML PDF (126.17 K)
Document Type: Original Article
DOI: 10.21608/zvjz.2017.7689
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Authors
Hoda Abd-Allah email 1; Mona M. AbdAlhady2; Magda N.A. Abdelall1; Sahar N. Mohamedy1; Waheeb D.M. Alharbi3; Adil O. Bahathiq3
1Animal Health Research Institute, Zagazig Laboratory, Egypt
2Physiology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt
3Physiology Department, Faculty of Medicine, Umm al Qura University, Makkah, KSA
Abstract
Polycystic ovaries syndrome (PCOS) is one of the most prevalent causes of reproductive failure. Its pathogenesis may be hormonal and immune disorder with hyperactivity of the sympathetic nervous system. The present study was conducted to demonstrate the effect of coleus forskohlii roots extract (CFE) in modulating the levels of some hormones and immune parameters of rats with androgen induced PCOS. Fifty immature female albino rats were divided into control group and androgen treated group that injected subcutaneously with 60 mg/kg BW/day androgen (Cidotestone) for 35 days to induce PCOS. Each group was subdivided into two subgroups. The first two subgroups received saline and 25 mg/kg BW of CFE, respectively while the other two subgroups received the same doses of Cidotestone and Cidotestone + CFE, respectively for 3 weeks. Blood samples were collected at the end of the experiment to estimate the levels of corticosterone, beta endorphin, total leucocytic count (TLC), cluster of differentiation 4 (CD+4), cluster of differentiation 8 (CD+8), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), immunoglobulin G (IgG) and immunoglobulin A (IgA). The results revealed a significant decrease in the concentrations of β endorphin, IL-2, TLC, CD+4, CD+8 and IgG, while corticosterone and IL-4 showed a significant increase in the androgen induced PCOS group. Rats treated with Cidotestone + CFE displayed normal values of all tested parameters except corticosterone, suggesting role of CFE in mediating both humoral and cellular immunity.
Keywords
Coleus forskohlii; Rats; Polycystic Ovaries Syndrome
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