ASTRAGALUS MEMBRANACEUS AND LONICERA JAPONICA: PROMISING FOR NOVEL SCHISTOSOMA MANSONI CONTROL APPROACH | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 10, Volume 48, Issue 2, August 2018, Page 335-342 PDF (666.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.12816/0050440 | ||||
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| Authors | ||||
| RANIA SAID HAMZA1; NAGLAA FATHY ABD EL-AAL1; DALIA SAID HAMZA2 | ||||
| 1Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Egypt. | ||||
| 2Department of Zoology, Faculty of Science, Banha University, Egypt. | ||||
| Abstract | ||||
| Immunostimulants have the ability to reduce susceptibility to different infections and to enhance the overall health. This study assessed the effect of Astragalus membranaceus and Lonicera japonica, Chinese herbs, on Biomphalaria alexandrina snails' susceptibility to Schistosoma mansoni infection and their consequences on certain biochemical parameters of these snails, promising for novel S. mansoni control approach. Four snails groups each included 50 snails; G1: was infected control, G2: was fed on 0.1% Astragalus extract, G3: was fed on 0.1% Lonicera extract and G4: was fed 0.1% Astragalus extract and 0.1% Lonicera extract. Snails were fed on immunostimmulants for 7 days then exposed to S. mansoni miracidia. The snails' survival rate significantly increased with decreased infection rate in groups exposed to a combination of both herbs with significant suppression in the cercarial production/infected snail in all treated groups compared to control group. A significant increase in the total hemocytic count, glucose and total protein content in soft tissues in all treated groups compared to the control group. Moreover, there was a significant increase of hemolymph total lipid and a significant decrease in aspartate transaminase (AST) and alanine transaminase (ALT) in snails groups treated with herbs compared to control group. A. membranaceus and L. japonica improved B. alexandrina' resistance to schistosomiasis mansoni as a novel control. | ||||
| Keywords | ||||
| Immune Response; Chinese herbs; Biomphalaria alexandrina; Schistosoma mansoni; infection rate; biochemical parameters | ||||
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