DETECTION OF CRYPTOSPORIDIUM-INDUCED INTESTINAL TISSUE ALTERATIONS IN DEXAMETHASONE TREATED & UN-TREATED MICE
ABDELMAKSOUD, H., ISMAIL, M., AMER, N., EL AKKAD, D., MAGDY, M. (2018). DETECTION OF CRYPTOSPORIDIUM-INDUCED INTESTINAL TISSUE ALTERATIONS IN DEXAMETHASONE TREATED & UN-TREATED MICE. EKB Journal Management System, 48(2), 449-458. doi: 10.12816/0050453
HAGAR F. ABDELMAKSOUD; MOUSA A.M. ISMAIL; NEIMAT M. AMER; DINA M. H. EL AKKAD; MONA MAGDY. "DETECTION OF CRYPTOSPORIDIUM-INDUCED INTESTINAL TISSUE ALTERATIONS IN DEXAMETHASONE TREATED & UN-TREATED MICE". EKB Journal Management System, 48, 2, 2018, 449-458. doi: 10.12816/0050453
ABDELMAKSOUD, H., ISMAIL, M., AMER, N., EL AKKAD, D., MAGDY, M. (2018). 'DETECTION OF CRYPTOSPORIDIUM-INDUCED INTESTINAL TISSUE ALTERATIONS IN DEXAMETHASONE TREATED & UN-TREATED MICE', EKB Journal Management System, 48(2), pp. 449-458. doi: 10.12816/0050453
ABDELMAKSOUD, H., ISMAIL, M., AMER, N., EL AKKAD, D., MAGDY, M. DETECTION OF CRYPTOSPORIDIUM-INDUCED INTESTINAL TISSUE ALTERATIONS IN DEXAMETHASONE TREATED & UN-TREATED MICE. EKB Journal Management System, 2018; 48(2): 449-458. doi: 10.12816/0050453

DETECTION OF CRYPTOSPORIDIUM-INDUCED INTESTINAL TISSUE ALTERATIONS IN DEXAMETHASONE TREATED & UN-TREATED MICE

Journal of the Egyptian Society of Parasitology
Article 23, Volume 48, Issue 2, August 2018, Page 449-458  XML PDF (890.09 K)
Document Type: Original Article
DOI: 10.12816/0050453
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Authors
HAGAR F. ABDELMAKSOUD1; MOUSA A.M. ISMAIL2; NEIMAT M. AMER1; DINA M. H. EL AKKAD2; MONA MAGDY1
1Department of Medical Parasitology and Pathology, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Giza 12411, Egypt.
2Department of Medical Parasitology, Faculty of Medicine, Cairo University, Giza, Egypt.
Abstract
Cryptosporidium parvum (C. parvum) is coccidian protozoan that causes cryptosporidiosis, a parasitic disease of the mammalian intestinal tract. C. parvum is considered one of the most important waterborne pathogen among the most relevant parasitic enteric agents in man and animals. It is resistant to all practical levels of chlorination and it is an obligate intracellular pathogen. It has been the cause of multiple diarrhea outbreaks in developed and developing countries. The present work was carried out to evaluate the pathological, immuno-histochemical and molecular changes in the ileocecal region induced by chronic irritation with different inoculum sizes of cryptosporidium (50,500 oocysts) in immunocompetent and immunosuppressed mice. The mice were euthanized at different dates starting from 14, 21, 36, 45, 57 till day 64 to study these transformations. Histopathological examination of the ileocecal region revealed neoplastic changes in the form of dysplasia, polypoid structures, architectural distortion, glandular crowding, marked cellular atypia, exophytic adenomatous polypi, intramuscular adenocarcinoma and marked nuclear anaplasia.
Keywords
Cryptosporidium spp. Mice; Intestinal tissue alterations; histopathology
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